PUBLICATION
Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo
- Authors
- Wu, P., Song, Z., Wang, X., Li, Y., Li, Y., Cui, J., Tuerhong, M., Jin, D.Q., Abudukeremu, M., Lee, D., Xu, J., Guo, Y.
- ID
- ZDB-PUB-200708-13
- Date
- 2020
- Source
- Bioorganic chemistry 101: 104004 (Journal)
- Registered Authors
- Cui, Jianlin, Li, Yuhao
- Keywords
- Anti-inflammatory properties, Euphane triterpenoids, Lantana camara, Molecular docking, Zebrafish model
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/chemistry
- Anti-Inflammatory Agents/pharmacology*
- Blotting, Western
- Cell Line
- In Vitro Techniques
- Lantana/chemistry*
- Mice
- Microglia/drug effects
- Microglia/metabolism
- Molecular Docking Simulation
- Nitric Oxide/metabolism
- Triterpenes/chemistry
- Triterpenes/pharmacology*
- Zebrafish
- PubMed
- 32629274 Full text @ Bioorg. Chem.
Citation
Wu, P., Song, Z., Wang, X., Li, Y., Li, Y., Cui, J., Tuerhong, M., Jin, D.Q., Abudukeremu, M., Lee, D., Xu, J., Guo, Y. (2020) Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo. Bioorganic chemistry. 101:104004.
Abstract
Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1-4) and six known (6-10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1-4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping