PUBLICATION
The Antimelanogenic Effect of Inularin Isolated from Flowers of Inula britannica on B16F10 Melanoma Cells and Zebrafish Embryos
- Authors
- Jang, D.K., Jung, S.H., Jeong, J.H., Yoo, H.M., Lee, I.S., Shin, H.S.
- ID
- ZDB-PUB-200603-11
- Date
- 2020
- Source
- Journal of microbiology and biotechnology 30: 749-752 (Journal)
- Registered Authors
- Jung, Seung-Hyun
- Keywords
- B16F10 melanoma cells, Inula britannica, inularin, melanogenesis, zebrafish embryos
- MeSH Terms
-
- Animals
- Cell Line, Tumor
- Embryo, Nonmammalian/drug effects
- Flowers/chemistry*
- Inula/chemistry*
- Melanins/analysis
- Melanins/metabolism*
- Melanoma/metabolism
- Mice
- Pigmentation/drug effects
- Sesquiterpenes*/chemistry
- Sesquiterpenes*/pharmacology
- Zebrafish
- PubMed
- 32482941 Full text @ J. Microbiol. Biotechnol.
Citation
Jang, D.K., Jung, S.H., Jeong, J.H., Yoo, H.M., Lee, I.S., Shin, H.S. (2020) The Antimelanogenic Effect of Inularin Isolated from Flowers of Inula britannica on B16F10 Melanoma Cells and Zebrafish Embryos. Journal of microbiology and biotechnology. 30:749-752.
Abstract
In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping