PUBLICATION
Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish
- Authors
- Suzuki, S., Kimura, R., Maegawa, S., Nakata, M., Hagiwara, M.
- ID
- ZDB-PUB-200508-1
- Date
- 2020
- Source
- Molecular brain 13: 70 (Journal)
- Registered Authors
- Maegawa, Shingo
- Keywords
- Atomoxetine, Attention deficit-hyperactivity disorder (ADHD), Behavior, Lipid metabolism, Methylphenidate, Transcriptome, Zebrafish
- MeSH Terms
-
- Animals
- Atomoxetine Hydrochloride/administration & dosage*
- Attention Deficit Disorder with Hyperactivity/drug therapy*
- Attention Deficit Disorder with Hyperactivity/genetics
- Attention Deficit Disorder with Hyperactivity/metabolism
- Behavior Rating Scale
- Brain/drug effects*
- Brain/metabolism
- Gene Ontology
- Lipid Metabolism
- Methylphenidate/administration & dosage*
- Signal Transduction/drug effects
- Signal Transduction/genetics
- Transcriptome/drug effects*
- Transcriptome/genetics
- Zebrafish
- PubMed
- 32375837 Full text @ Mol. Brain
Citation
Suzuki, S., Kimura, R., Maegawa, S., Nakata, M., Hagiwara, M. (2020) Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish. Molecular brain. 13:70.
Abstract
Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxetine (ATX) are commonly prescribed for the treatment of ADHD. In the present study, we examined the behavioral and brain transcriptome changes in MPH-treated and ATX-treated zebrafish. In behavioral analysis, zebrafish showed opposite response to each treatment. MPH-treated fish showed higher anxiety-like behavior while ATX-treated fish showed lower anxiety-like behavior. Further, we performed RNA sequencing analysis of zebrafish brain to elucidate the underlying biological pathways associated with MPH and ATX treatment. Interestingly, we found that shared differentially expressed genes in MPH-treated and ATX-treated fish were instrumental in cholesterol biosynthesis pathway and were regulated in opposite manner. Our findings highlight the contrast between MTH and ATX, and may suggest the alterations in clinical practice for these medications and drug development for ADHD.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping