PUBLICATION
Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners
- Authors
- Tunbak, H., Vazquez-Prada, M.C., Ryan, T.M., Kampff, A.R., Dreosti, E.
- ID
- ZDB-PUB-200506-3
- Date
- 2020
- Source
- eLIFE 9: (Journal)
- Registered Authors
- Dreosti, Elena
- Keywords
- neuroscience, zebrafish
- MeSH Terms
-
- Animals
- Brain/physiology*
- Brain Mapping*
- In Situ Hybridization, Fluorescence
- Social Behavior*
- Social Isolation*
- Zebrafish/physiology*
- PubMed
- 32366356 Full text @ Elife
Citation
Tunbak, H., Vazquez-Prada, M.C., Ryan, T.M., Kampff, A.R., Dreosti, E. (2020) Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners. eLIFE. 9:.
Abstract
The zebrafish was used to assess the impact of social isolation on behaviour and brain function. As in humans and other social species, early social deprivation reduced social preference in juvenile zebrafish. Whole-brain functional maps of anti-social isolated (lonely) fish were distinct from anti-social (loner) fish found in the normal population. These isolation-induced activity changes revealed profound disruption of neural activity in brain areas linked to social behaviour, social cue processing, and anxiety/stress. Several of the affected regions are modulated by serotonin, and we found that social preference in isolated fish could be rescued by acutely reducing serotonin levels.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping