PUBLICATION
Pediatric Cancer Models in Zebrafish
- Authors
- Casey, M.J., Stewart, R.A.
- ID
- ZDB-PUB-200430-13
- Date
- 2020
- Source
- Trends in cancer 6: 407-418 (Review)
- Registered Authors
- Stewart, Rodney A.
- Keywords
- brain tumors, cancer, leukemia, pediatric, sarcoma, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Antineoplastic Agents/pharmacology
- Antineoplastic Agents/therapeutic use
- Carcinogenesis/genetics
- Carcinogenesis/pathology
- Child
- Disease Models, Animal*
- Embryo, Nonmammalian
- High-Throughput Screening Assays/methods*
- Humans
- Intravital Microscopy
- Mice
- Neoplasms/diagnosis
- Neoplasms/drug therapy
- Neoplasms/genetics*
- Neoplasms/pathology
- Oncogenes/genetics
- Time Factors
- Xenograft Model Antitumor Assays
- Zebrafish*
- PubMed
- 32348736 Full text @ Trends Cancer
Citation
Casey, M.J., Stewart, R.A. (2020) Pediatric Cancer Models in Zebrafish. Trends in cancer. 6:407-418.
Abstract
Pediatric cancer is a leading cause of death in children and adolescents. Improvements in pediatric cancer treatment that include the alleviation of long-term adverse effects require a deeper understanding of the genetic, epigenetic, and developmental factors driving these cancers. Here, we review how the unique attributes of the zebrafish model system in embryology, imaging, and scalability have been used to identify new mechanisms of tumor initiation, progression, and relapse and for drug discovery. We focus on zebrafish models of leukemias, neural tumors and sarcomas - the most common and difficult childhood cancers to treat.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping