PUBLICATION
Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae
- Authors
- Haindl, R., Deloria, A.J., Sturtzel, C., Sattmann, H., Rohringer, W., Fischer, B., Andreana, M., Unterhuber, A., Schwerte, T., Distel, M., Drexler, W., Leitgeb, R., Liu, M.
- ID
- ZDB-PUB-200429-8
- Date
- 2020
- Source
- Biomedical Optics Express 11: 2137-2151 (Journal)
- Registered Authors
- Distel, Martin, Schwerte, Thorsten, Sturtzel, Caterina
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 32341872 Full text @ Biomed. Opt. Express
Citation
Haindl, R., Deloria, A.J., Sturtzel, C., Sattmann, H., Rohringer, W., Fischer, B., Andreana, M., Unterhuber, A., Schwerte, T., Distel, M., Drexler, W., Leitgeb, R., Liu, M. (2020) Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae. Biomedical Optics Express. 11:2137-2151.
Abstract
We present a dual modality functional optical coherence tomography and photoacoustic microscopy (OCT-PAM) system. The photoacoustic modality employs an akinetic optical sensor with a large imaging window. This imaging window enables direct reflection mode operation, and a seamless integration of optical coherence tomography (OCT) as a second imaging modality. Functional extensions to the OCT-PAM system include Doppler OCT (DOCT) and spectroscopic PAM (sPAM). This functional and non-invasive imaging system is applied to image zebrafish larvae, demonstrating its capability to extract both morphological and hemodynamic parameters in vivo in small animals, which are essential and critical in preclinical imaging for physiological, pathophysiological and drug response studies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping