ZFIN ID: ZDB-PUB-200429-13
Reprogramming Müller Glia to Regenerate Retinal Neurons
Lahne, M., Nagashima, M., Hyde, D.R., Hitchcock, P.F.
Date: 2020
Source: Annual review of vision science   6: 171-193 (Other)
Registered Authors: Hitchcock, Peter, Hyde, David R., Nagashima, Mikiko
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Cell Differentiation
  • DNA Methylation
  • Ependymoglial Cells/physiology*
  • Epigenomics
  • Humans
  • Nerve Regeneration/physiology*
  • Receptors, Notch/metabolism
  • Retinal Neurons/cytology
  • Retinal Neurons/physiology*
  • Signal Transduction
  • Stem Cells
  • Zebrafish
PubMed: 32343929 Full text @ Annu Rev Vis Sci
In humans, various genetic defects or age-related diseases, such as diabetic retinopathies, glaucoma, and macular degeneration, cause the death of retinal neurons and profound vision loss. One approach to treating these diseases is to utilize stem and progenitor cells to replace neurons in situ, with the expectation that new neurons will create new synaptic circuits or integrate into existing ones. Reprogramming non-neuronal cells in vivo into stem or progenitor cells is one strategy for replacing lost neurons. Zebrafish have become a valuable model for investigating cellular reprogramming and retinal regeneration. This review summarizes our current knowledge regarding spontaneous reprogramming of Müller glia in zebrafish and compares this knowledge to research efforts directed toward reprogramming Müller glia in mammals. Intensive research using these animal models has revealed shared molecular mechanisms that make Müller glia attractive targets for cellular reprogramming and highlight the potential for curing degenerative retinal diseases from intrinsic cellular sources. Expected final online publication date for the Annual Review of Vision Science, Volume 6 is September 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.