ZFIN ID: ZDB-PUB-200423-9
Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin
Vonica, A., Bhat, N., Phan, K., Guo, J., Iancu, L., Weber, J.A., Karger, A., Cain, J.W., Wang, E.C.E., DeStefano, G.M., O'Donnell-Luria, A.H., Christiano, A.M., Riley, B., Butler, S.J., Luria, V.
Date: 2020
Source: Developmental Biology   464(1): 71-87 (Journal)
Registered Authors: Riley, Bruce
Keywords: Apcdd1, Bi-functional protein, Chicken, Embryonic development, Mouse, Wnt and BMP signaling Inhibitor, Xenopus, Zebrafish
MeSH Terms:
  • Animals
  • Body Patterning*
  • Bone Morphogenetic Proteins/genetics
  • Bone Morphogenetic Proteins/metabolism*
  • Embryo, Nonmammalian/embryology*
  • Membrane Glycoproteins/genetics
  • Membrane Glycoproteins/metabolism*
  • Protein Domains
  • Wnt Signaling Pathway*
  • Xenopus Proteins/genetics
  • Xenopus Proteins/metabolism*
  • Xenopus laevis
PubMed: 32320685 Full text @ Dev. Biol.
Animal development and homeostasis depend on precise temporal and spatial intercellular signaling. Components shared between signaling pathways, generally thought to decrease specificity, paradoxically can also provide a solution to pathway coordination. Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcdd1 is a taxon-restricted gene with novel domains and signaling functions. Previously, we showed that Apcdd1 inhibits Wnt signaling (Shimomura et al., 2010), here we find that Apcdd1 potently inhibits BMP signaling in body axis formation and neural differentiation in chicken, frog, zebrafish. Furthermore, we find that Apcdd1 has an evolutionarily novel protein domain. Our results from experiments and modeling suggest that Apcdd1 may coordinate the outputs of two signaling pathways that are central to animal development and human disease.