PUBLICATION
Histological development and integration of the Zebrafish Weberian apparatus
- Authors
- Bird, N.C., Richardson, S.S., Abels, J.R.
- ID
- ZDB-PUB-200422-9
- Date
- 2020
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 249(8): 998-1017 (Journal)
- Registered Authors
- Bird, Nathan C.
- Keywords
- Danio rerio, Weberian ossicles, inner ear, ontogeny, ossification, soft tissue, swim bladder
- MeSH Terms
-
- Air Sacs/anatomy & histology
- Air Sacs/embryology
- Air Sacs/growth & development
- Animals
- Ear/anatomy & histology
- Ear/embryology*
- Ear/growth & development*
- Ear Ossicles/anatomy & histology
- Ear Ossicles/embryology
- Ear Ossicles/growth & development
- Gene Expression Regulation, Developmental*
- Hearing
- Larva
- Ligaments/anatomy & histology
- Ligaments/embryology
- Ligaments/growth & development
- Morphogenesis
- Osteogenesis*
- Species Specificity
- Temperature
- Zebrafish/embryology*
- Zebrafish/growth & development*
- PubMed
- 32243643 Full text @ Dev. Dyn.
Citation
Bird, N.C., Richardson, S.S., Abels, J.R. (2020) Histological development and integration of the Zebrafish Weberian apparatus. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(8):998-1017.
Abstract
Background The Weberian apparatus enhances hearing in otophysan fishes, including Zebrafish (Danio rerio). Several studies have examined aspects of morphological development of the Weberian apparatus and hearing ability in Zebrafish. A comprehensive developmental description including both hard and soft tissues is lacking. This information is critical for both interpretation of genetic developmental analyses and to better understand the role of morphogenesis and integration on changes in hearing ability.
Results Histological development of hard and soft tissues of the Weberian apparatus, including ossicles, ear, swim bladder, and ligaments are described from early larval stages (3.8 mm notochord length) through adult. Results show a strong relationship in developmental timing and maturation across all regions. All required auditory elements are present and morphologically integrated early, by 6.5 mm SL. Dynamic ossification patterns and changes in shape continue throughout the examined developmental period.
Conclusions This study provides the first comprehensive histological description of Weberian apparatus development in Zebrafish. Morphological integration was found early, before increases in hearing ability were detected in functional studies (>10 mm total length), suggesting morphological integration precedes functional integration. Further research is needed to examine the nature of the functional delay, and how maturation of the Weberian apparatus influences functionality.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping