PUBLICATION

Antioxidant Potential of Sulfated Polysaccharides from Padina boryana; Protective Effect against Oxidative Stress in In Vitro and In Vivo Zebrafish Model

Authors
Jayawardena, T.U., Wang, L., Sanjeewa, K.K.A., Kang, S.I., Lee, J.S., Jeon, Y.J.
ID
ZDB-PUB-200422-130
Date
2020
Source
Marine drugs   18(4): (Journal)
Registered Authors
Jeon, You-Jin
Keywords
Maldives, Padina boryana, antioxidant, sulfated polysaccharide, zebrafish
MeSH Terms
  • Animals
  • Antioxidants/chemistry*
  • Antioxidants/pharmacology
  • Models, Animal
  • Oxidative Stress/drug effects
  • Phaeophyceae*
  • Polysaccharides/chemistry*
  • Polysaccharides/pharmacology
  • Zebrafish*
PubMed
32295194 Full text @ Mar. Drugs
Citation
Jayawardena, T.U., Wang, L., Sanjeewa, K.K.A., Kang, S.I., Lee, J.S., Jeon, Y.J. (2020) Antioxidant Potential of Sulfated Polysaccharides from Padina boryana; Protective Effect against Oxidative Stress in In Vitro and In Vivo Zebrafish Model. Marine drugs. 18(4):.
Abstract
Elevated levels of reactive oxygen species (ROS) damage the internal cell components. Padina boryana, a brown alga from the Maldives, was subjected to polysaccharide extraction. The Celluclast enzyme assisted extract (PBE) and ethanol precipitation (PBP) of P. boryana were assessed against hydrogen peroxide (H2O2) induced cell damage and zebra fish models. PBP which contains the majority of sulfated polysaccharides based on fucoidan, showed outstanding extracellular ROS scavenging potential against H2O2. PBP significantly declined the intracellular ROS levels, and exhibited protection against apoptosis. The study revealed PBPs' ability to activate the Nrf2/Keap1 signaling pathway, consequently initiating downstream elements such that catalase (CAT) and superoxide dismutase (SOD). Further, ROS levels, lipid peroxidation values in zebrafish studies were declined with the pre-treatment of PBP. Collectively, the results obtained in the study suggest the polysaccharides from P. boryana might be a potent source of water soluble natural antioxidants that could be sustainably utilized in the industrial applications.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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