PUBLICATION
The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning
- Authors
- Yan, Y., Ning, G., Li, L., Liu, J., Yang, S., Cao, Y., Wang, Q.
- ID
- ZDB-PUB-200221-16
- Date
- 2019
- Source
- Science advances 5: eaau6455 (Journal)
- Registered Authors
- Wang, Qiang
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning*
- Bone Morphogenetic Proteins/metabolism*
- Carrier Proteins/metabolism*
- Embryo, Nonmammalian
- Embryonic Development
- Gene Expression Regulation, Developmental
- Ligands
- Signal Transduction
- Smad Proteins/metabolism
- Zebrafish/metabolism
- Zebrafish Proteins/metabolism*
- PubMed
- 32064309 Full text @ Sci Adv
Citation
Yan, Y., Ning, G., Li, L., Liu, J., Yang, S., Cao, Y., Wang, Q. (2019) The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning. Science advances. 5:eaau6455.
Abstract
Vertebrate embryonic dorsoventral axis is robustly stable in the face of variations in bone morphogenetic protein (BMP) signaling. However, the molecular mechanism behind this robustness remains uncharacterized. In this study, we show that zebrafish Pinhead, together with Admp, plays an important compensatory role in ensuring the robustness of axial patterning through fine-tuning of BMP signaling. pinhead encodes a BMP-like ligand expressed in the ventrolateral margin of the early gastrula. Transcription of pinhead and admp is under opposing regulation, where pinhead depletion results in a compensatory increase in admp transcription and vice versa, leading to normal axis formation in pinhead or admp mutants. Expression of pinhead and admp is directly repressed by the BMP/Smad pathway. When BMP signals were inhibited or excessively activated, pinhead/admp expression changed accordingly, allowing for self-regulation. Thus, this study reveals a negative feedback loop between BMP signaling and pinhead/admp that effectively stabilizes embryonic patterning by buffering against fluctuations in BMP signaling.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping