PUBLICATION

Mechanisms of zebrafish epiboly: A current view

Authors
Bruce, A.E.E., Heisenberg, C.P.
ID
ZDB-PUB-200122-1
Date
2020
Source
Current topics in developmental biology   136: 319-341 (Chapter)
Registered Authors
Bruce, Ashley, Heisenberg, Carl-Philipp
Keywords
Enveloping layer, Gastrulation, Morphogenesis, Radial intercalation, Yolk syncytial layer
MeSH Terms
  • Animals
  • Blastoderm/cytology
  • Blastoderm/physiology*
  • Body Patterning*
  • Cell Movement
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/physiology*
  • Epithelium/physiology*
  • Gastrula/cytology
  • Gastrula/physiology
  • Gastrulation*
  • Gene Expression Regulation, Developmental
  • Morphogenesis*
  • Transcription Factors
  • Zebrafish/embryology
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
31959293 Full text @ Curr. Top. Dev. Biol.
Abstract
Epiboly is a conserved gastrulation movement describing the thinning and spreading of a sheet or multi-layer of cells. The zebrafish embryo has emerged as a vital model system to address the cellular and molecular mechanisms that drive epiboly. In the zebrafish embryo, the blastoderm, consisting of a simple squamous epithelium (the enveloping layer) and an underlying mass of deep cells, as well as a yolk nuclear syncytium (the yolk syncytial layer) undergo epiboly to internalize the yolk cell during gastrulation. The major events during zebrafish epiboly are: expansion of the enveloping layer and the internal yolk syncytial layer, reduction and removal of the yolk membrane ahead of the advancing blastoderm margin and deep cell rearrangements between the enveloping layer and yolk syncytial layer to thin the blastoderm. Here, work addressing the cellular and molecular mechanisms as well as the sources of the mechanical forces that underlie these events is reviewed. The contribution of recent findings to the current model of epiboly as well as open questions and future prospects are also discussed.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping