PUBLICATION

Transcriptional adaptation in Caenorhabditis elegans

Authors
Serobyan, V., Kontarakis, Z., El-Brolosy, M.A., Welker, J.M., Tolstenkov, O., Saadeldein, A.M., Retzer, N., Gottschalk, A., Wehman, A.M., Stainier, D.Y.
ID
ZDB-PUB-200118-23
Date
2020
Source
eLIFE   9: (Journal)
Registered Authors
Kontarakis, Zacharias, Stainier, Didier, Wehman, Ann
Keywords
C. elegans, RNAi, chromosomes, gene expression, genetics, genomics, mRNA decay, small RNA, transcriptional adaptation
MeSH Terms
  • Adaptation, Biological/genetics*
  • Animals
  • Argonaute Proteins/genetics
  • Argonaute Proteins/metabolism
  • Caenorhabditis elegans/genetics*
  • Caenorhabditis elegans Proteins/genetics
  • Caenorhabditis elegans Proteins/metabolism
  • DEAD-box RNA Helicases/genetics
  • DEAD-box RNA Helicases/metabolism
  • Gene Expression Regulation/genetics*
  • Mutation/genetics
  • RNA Stability/genetics
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Ribonuclease III/genetics
  • Ribonuclease III/metabolism
  • Transcription, Genetic/genetics*
PubMed
31951195 Full text @ Elife
Abstract
Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed that the mutant mRNA, rather than the loss of protein function, activates this response. While several examples of transcriptional adaptation have been reported in zebrafish embryos and in mouse cell lines, it is not known whether this phenomenon is observed across metazoans. Here we report transcriptional adaptation in C. elegans, and find that this process requires factors involved in mutant mRNA decay, as in zebrafish and mouse. We further uncover a requirement for Argonaute proteins and Dicer, factors involved in small RNA maturation and transport into the nucleus. Altogether, these results provide evidence for transcriptional adaptation in C. elegans, a powerful model to further investigate underlying molecular mechanisms.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping