PUBLICATION
Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis
- Authors
- Bae, H., Lee, J.Y., Yang, C., Song, G., Lim, W.
- ID
- ZDB-PUB-200116-4
- Date
- 2020
- Source
- Marine drugs 18(1): (Journal)
- Registered Authors
- Keywords
- angiogenesis, calcium homeostasis, fucoidan, marine drug, ovarian cancer
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/pharmacology
- Calcium/metabolism*
- Cell Line, Tumor
- Cell Proliferation/drug effects
- Endoplasmic Reticulum/drug effects
- Female
- Fucus/chemistry*
- Homeostasis/drug effects*
- Humans
- Neovascularization, Pathologic/prevention & control
- Ovarian Neoplasms/drug therapy
- Polysaccharides/pharmacology*
- Polysaccharides/toxicity
- Stress, Physiological/drug effects*
- Toxicity Tests
- Zebrafish
- PubMed
- 31936539 Full text @ Mar. Drugs
Citation
Bae, H., Lee, J.Y., Yang, C., Song, G., Lim, W. (2020) Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis. Marine drugs. 18(1):.
Abstract
Marine organisms are sources of several natural compounds with potential clinical use. However, only a few marine-based pharmaceuticals have been approved for use due to limited knowledge on their biological activities. Here, we identified the functional role of fucoidan extracted from Fucus vesiculosus on ovarian cancer. Fucoidan increased the death of ES-2 and OV-90 cells, through a reduction in proliferation, cell cycle arrest, releases of cytochrome c, reactive oxygen species (ROS) generation, and endoplasmic reticulum (ER) stress. Additionally, fucoidan increased the concentration of cytosolic and mitochondrial calcium in both cells. The decrease of cell proliferation was controlled by the inactivation of PI3K and MAPK signaling cascades in ES-2 and OV-90 cells. In a toxicity assay with normal zebrafish larvae, fucoidan did not induce toxicity, cardiotoxicity, development, kinesis, and apoptosis at different concentrations. However, it disrupted tumor formation and vascular development in a zebrafish xenograft model and angiogenesis transgenic (Tg, fli1-eGFP) model, respectively. Collectively, the results indicate that fucoidan may be a novel pharmaceutical for the management of human ovarian cancer.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping