PUBLICATION
Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish
- Authors
- Rosowski, E.E.
- ID
- ZDB-PUB-200115-1
- Date
- 2020
- Source
- Disease models & mechanisms 13(1): (Review)
- Registered Authors
- Rosowski, Emily E.
- Keywords
- Innate immunity, Larval zebrafish, Macrophages, Neutrophils
- MeSH Terms
-
- Animals
- Cell Proliferation
- Disease Models, Animal
- Immunity, Innate/immunology*
- Larva/immunology
- Macrophages/physiology*
- Metronidazole/pharmacology
- Mice
- Microglia/physiology
- Neutrophils/physiology*
- Zebrafish/immunology*
- PubMed
- 31932292 Full text @ Dis. Model. Mech.
Citation
Rosowski, E.E. (2020) Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish. Disease models & mechanisms. 13(1):.
Abstract
The specific roles of the two major innate immune cell types - neutrophils and macrophages - in response to infection and sterile inflammation are areas of great interest. The larval zebrafish model of innate immunity, and the imaging capabilities it provides, is a source of new research and discoveries in this field. Multiple methods have been developed in larval zebrafish to specifically deplete functional macrophages or neutrophils. Each of these has pros and cons, as well as caveats, that often make it difficult to directly compare results from different studies. The purpose of this Review is to (1) explore the pros, cons and caveats of each of these immune cell-depleted models; (2) highlight and place into a broader context recent key findings on the specific functions of innate immune cells using these models; and (3) explore future directions in which immune cell depletion methods are being expanded.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping