ZFIN ID: ZDB-PUB-191201-5
Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action
van Staden, C., de Brouwer, G., Botha, T.L., Finger-Baier, K., Brand, S.J., Wolmarans, D.
Date: 2019
Source: Behavioural brain research   379: 112393 (Journal)
Registered Authors: Finger-Baier, Karin
Keywords: dopamine, inflexibility, obsessive-compulsive disorder, opponency, serotonin, zebrafish
MeSH Terms:
  • Animals
  • Apomorphine/pharmacology
  • Behavior, Animal/drug effects*
  • Citalopram/pharmacology
  • Conflict, Psychological
  • Disease Models, Animal
  • Dopamine Agonists/administration & dosage
  • Dopamine Agonists/pharmacology*
  • Feedback, Psychological
  • Motivation/drug effects*
  • Obsessive-Compulsive Disorder/drug therapy*
  • Reward*
  • Serotonin Uptake Inhibitors/administration & dosage
  • Serotonin Uptake Inhibitors/pharmacology*
  • Social Behavior*
  • Zebrafish
PubMed: 31785362 Full text @ Behav. Brain Res.
Cognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test for anti-compulsive drug action, we manipulated social reward appraisal under different contexts by means of dopaminergic (apomorphine) and serotonergic (escitalopram) intervention. Seven groups of zebrafish (n = 6 per group) were exposed for 24 days (1 h per day) to either control (normal tank water), apomorphine (50 or 100 μ g/L), escitalopram (500 or 1000 μ g/L) or a combination (A100/E500 or A100/E1000 μ g/L). Contextual reward appraisal was assessed over three phases i.e. Phase 1 (contingency association), Phase 2 (dissociative testing), and Phase 3 (re-associative testing). We demonstrate that 1) sight of social conspecifics is an inadequate motivational reinforcer under circumstances of motivational conflict, 2) dopaminergic and serotonergic intervention lessens the importance of an aversive stimulus, increasing the motivational valence of social reward, 3) while serotoninergic intervention maintains reward directed behavior, high-dose dopaminergic intervention bolsters cue-directed responses and 4) high-dose escitalopram reversed apomorphine-induced behavioral inflexibility. The results reported here are supportive of current dopamine-serotonin opponency theories and confirm the zebrafish as a potentially useful species in which to mimic compulsive-like behaviors.