|ZFIN ID: ZDB-PUB-191126-10|
New function of zebrafish regulatory T cells in organ regeneration
|Source:||Current opinion in immunology 63: 7-13 (Review)|
|Registered Authors:||Kikuchi, Kazu|
|PubMed:||31765917 Full text @ Curr. Opin. Immunol.|
Kikuchi, K. (2019) New function of zebrafish regulatory T cells in organ regeneration. Current opinion in immunology. 63:7-13.
ABSTRACTZebrafish can efficiently regenerate complex tissue structures with a highly developed innate and adaptive immune system, which provides a model to investigate the roles of immune cells in tissue repair and regeneration. Two groups recently reported zebrafish mutants deficient in a forkhead box P3 (FOXP3) ortholog, which helped reveal the conserved immunosuppressive function of zebrafish FOXP3 in vivo. Zebrafish FOXP3 defines the development of a subset of T cell lineage with the conserved gene expression profile of mammalian regulatory T cells (Tregs). In damaged organs, zebrafish Tregs rapidly migrate to the injury site, where they promote the proliferation of regeneration precursor cells by producing tissue-specific regenerative factors through a distinct mechanism from the canonical anti-inflammatory pathway. These findings illuminate the potential for using zebrafish as an effective model in Treg research and demonstrate organ-specific roles for Tregs in maintaining proregenerative capacity that could potentially be harnessed for use in diverse regeneration therapies.
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