PUBLICATION
Interkingdom Genetic Mix-and-Match To Produce Novel Sunscreens
- Authors
- Osborn, A.R., Mahmud, T.
- ID
- ZDB-PUB-191116-1
- Date
- 2019
- Source
- ACS synthetic biology 8: 2464-2471 (Journal)
- Registered Authors
- Keywords
- Rhodococcus, Streptomyces, gadusol, gadusporine, mycosporine-like amino acid, sunscreen, zebra fish
- MeSH Terms
-
- Metabolic Engineering/methods*
- Rhodococcus/genetics*
- Sunscreening Agents/chemical synthesis*
- Amino Acids/chemistry
- Cyclohexanols/chemistry
- Ultraviolet Rays
- Zebrafish/genetics*
- Skin Cream/chemistry
- Anthozoa/drug effects
- Streptomyces coelicolor/metabolism*
- Animals
- Plasmids/genetics
- Benzophenones/adverse effects
- Benzophenones/pharmacology
- Streptomyces/genetics*
- Cinnamates/adverse effects
- Cinnamates/pharmacology
- PubMed
- 31689088 Full text @ ACS Synth Biol
Citation
Osborn, A.R., Mahmud, T. (2019) Interkingdom Genetic Mix-and-Match To Produce Novel Sunscreens. ACS synthetic biology. 8:2464-2471.
Abstract
Sunscreen-containing skincare products protect the skin from damage caused by sun exposure. However, many of them contain oxybenzone and/or octinoxate, which have been reported to be toxic to juvenile coral and to cause coral bleaching. Thus, there is a growing need for new sunscreen compounds that are less harmful to the environment. Here, we report an engineered biosynthetic pathway employing genes from a vertebrate and two Gram-(+) bacteria that forms novel sunscreen compounds with hybrid structures of gadusol and mycosporine-like amino acids, both of which are found in marine environments. These compounds, named gadusporines, have unique UV absorbance at 340 nm, expanding the range of mycosporine- and gadusol-based sunscreen products. The synthesis of gadusporines in Streptomyces coelicolor establishes a platform for the design and production of novel sunscreens.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping