PUBLICATION
Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
- Authors
- Djannatian, M., Timmler, S., Arends, M., Luckner, M., Weil, M.T., Alexopoulos, I., Snaidero, N., Schmid, B., Misgeld, T., Möbius, W., Schifferer, M., Peles, E., Simons, M.
- ID
- ZDB-PUB-191024-2
- Date
- 2019
- Source
- Nature communications 10: 4794 (Journal)
- Registered Authors
- Djannatian, Minou Susan, Schmid, Bettina, Simons, Mikael
- Keywords
- none
- MeSH Terms
-
- Female
- Animals
- Central Nervous System/physiology*
- Zebrafish/genetics
- Larva
- Axons/physiology*
- Myelin-Associated Glycoprotein/genetics
- Myelin-Associated Glycoprotein/metabolism
- Neural Cell Adhesion Molecules/genetics
- Neural Cell Adhesion Molecules/metabolism*
- Animals, Genetically Modified
- Myelin Sheath/pathology
- Myelin Sheath/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Mice, Transgenic
- Cell Adhesion Molecules, Neuronal/genetics
- Cell Adhesion Molecules, Neuronal/metabolism
- Male
- Contactin 1/genetics
- Contactin 1/metabolism
- Cell Adhesion/physiology
- Mice, Inbred C57BL
- Optic Nerve/metabolism
- Optic Nerve/pathology
- PubMed
- 31641127 Full text @ Nat. Commun.
Citation
Djannatian, M., Timmler, S., Arends, M., Luckner, M., Weil, M.T., Alexopoulos, I., Snaidero, N., Schmid, B., Misgeld, T., Möbius, W., Schifferer, M., Peles, E., Simons, M. (2019) Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS. Nature communications. 10:4794.
Abstract
Central nervous system myelin is a multilayered membrane produced by oligodendrocytes to increase neural processing speed and efficiency, but the molecular mechanisms underlying axonal selection and myelin wrapping are unknown. Here, using combined morphological and molecular analyses in mice and zebrafish, we show that adhesion molecules of the paranodal and the internodal segment work synergistically using overlapping functions to regulate axonal interaction and myelin wrapping. In the absence of these adhesive systems, axonal recognition by myelin is impaired with myelin growing on top of previously myelinated fibers, around neuronal cell bodies and above nodes of Ranvier. In addition, myelin wrapping is disturbed with the leading edge moving away from the axon and in between previously formed layers. These data show how two adhesive systems function together to guide axonal ensheathment and myelin wrapping, and provide a mechanistic understanding of how the spatial organization of myelin is achieved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping