PUBLICATION

A bidirectional network for appetite control in larval zebrafish

Authors
Wee, C.L., Song, E.Y., Johnson, R.E., Ailani, D., Randlett, O., Kim, J.Y., Nikitchenko, M., Bahl, A., Yang, C.T., Ahrens, M.B., Kawakami, K., Engert, F., Kunes, S.
ID
ZDB-PUB-191022-17
Date
2019
Source
eLIFE   8: (Journal)
Registered Authors
Ahrens, Misha, Engert, Florian, Kawakami, Koichi, Randlett, Owen, Yang, Chao-Tsung
Keywords
appetite, hypothalamus, neuroscience, serotonin, zebrafish
MeSH Terms
  • Animals
  • Appetite*
  • Hypothalamus/physiology*
  • Larva/physiology
  • Nerve Net/physiology*
  • Serotonergic Neurons/physiology*
  • Zebrafish/physiology*
PubMed
31625906 Full text @ Elife
Abstract
Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here we report that, in larval zebrafish, primarily serotonergic neurons of the ventromedial caudal hypothalamus (cH) become increasingly active during food deprivation, whereas activity in the lateral hypothalamus (LH) is reduced. Exposure to food sensory and consummatory cues reverses the activity patterns of these two nuclei, consistent with their representation of opposing internal hunger states. Baseline activity is restored as food-deprived animals return to satiety via voracious feeding. The antagonistic relationship and functional importance of cH and LH activity patterns were confirmed by targeted stimulation and ablation of cH neurons. Collectively, the data allow us to propose a model in which these hypothalamic nuclei regulate different phases of hunger and satiety and coordinate energy balance via antagonistic control of distinct behavioral outputs.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes