ZFIN ID: ZDB-PUB-191011-10
Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
Wang, C., Gong, S., Liang, Z., Sun, Y., Cheng, R., Yang, B., Liu, Y., Yang, J., Sun, F.
Date: 2019
Source: ACS omega   4: 16045-16051 (Journal)
Registered Authors: Sun, Fei
Keywords: none
MeSH Terms: none
PubMed: 31592175 Full text @ ACS Omega
ABSTRACT
A ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application has been developed. Highly chemical selectivity control is achieved based on ligand regulation. 1,2-Bis(diphenylphosphino)ethane was found to be critical for the transfer hydrogenation of alkynes. The general applicability of this procedure is highlighted by the synthesis of 30 terminal alkenes with a good yield. In addition, we conducted drug effect studies of phenelzine using zebrafish as the vertebrate model. Phenelzine shows a significant effect on promoting vascular proliferation and inhibiting nerve growth. The results of these studies have an important reference value for promoting drug research in cerebrovascular diseases, epilepsy, mania, and psychosis.
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