ZFIN ID: ZDB-PUB-190913-8
Kv2.1 voltage-gated potassium channel et al. in developmental perspective
Jędrychowska, J., Korzh, V.
Date: 2019
Source: Developmental dynamics : an official publication of the American Association of Anatomists   248(12): 1180-1194 (Review)
Registered Authors: Jędrychowska, Justyna, Korzh, Vladimir
Keywords: Kcnb1, Kcng4, N- and C-terminals, brain ventricular system, neurodevelopmental diseases, microcephaly, hydrocephalus, zebrafish
MeSH Terms:
  • Animals
  • Brain/embryology
  • Brain/growth & development
  • Growth and Development/genetics*
  • Humans
  • Neurodevelopmental Disorders/genetics
  • Reproduction/genetics
  • Shab Potassium Channels/physiology*
PubMed: 31512327 Full text @ Dev. Dyn.
ABSTRACT
Kv2.1 voltage-gated potassium channels consist of two types of α-subunits: (1) electrically-active Kcnb1 α-subunits and (2) silent or modulatory α-subunits plus β-subunits that, similar to silent α-subunits, also regulate electrically-active subunits. Voltage-gated potassium channels were traditionally viewed, mainly by electrophysiologists, as regulators of the electrical activity of the plasma membrane in excitable cells, a role that is performed by transmembrane protein domains of α-subunits that form the electric pore. Genetic studies revealed a role for this region of α-subunits of voltage-gated potassium channels in human neurodevelopmental disorders, such as epileptic encephalopathy. The N- and C-terminal domains of α-subunits interact to form the cytoplasmic subunit of hetero-tetrameric potassium channels that regulate electric pores. Subsequent animal studies revealed the developmental functions of Kcnb1-containing voltage-gated potassium channels and illustrated their role during brain development and reproduction. These functions of potassium channels are discussed in this review in the context of regulatory interactions between electrically-active and regulatory subunits. This article is protected by copyright. All rights reserved.
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