PUBLICATION

Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

Authors
Wei, L., Al Oustah, A., Blader, P., Roussigné, M.
ID
ZDB-PUB-190910-11
Date
2019
Source
eLIFE   8: (Journal)
Registered Authors
Al Oustah, Amir, Blader, Patrick, Roussigné, Myriam
Keywords
FGF pathway, cell biology, collective cell migration, developmental biology, left right asymmetry, notch signaling, zebrafish
MeSH Terms
  • Animals
  • Cell Movement*
  • Epithalamus/embryology*
  • Fibroblast Growth Factors/metabolism*
  • Gene Expression Regulation, Developmental
  • Gene Regulatory Networks
  • Receptors, Notch/metabolism*
  • Signal Transduction*
  • Zebrafish/embryology*
PubMed
31498774 Full text @ Elife
Abstract
Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping