PUBLICATION
Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity
- Authors
- Parveen, S., Hanif, M., Leung, E., Tong, K.K.H., Yang, A., Astin, J., De Zoysa, G.H., Steel, T.R., Goodman, D., Movassaghi, S., Söhnel, T., Sarojini, V., Jamieson, S.M.F., Hartinger, C.G.
- ID
- ZDB-PUB-190910-10
- Date
- 2019
- Source
- Chemical communications (Cambridge, England) 55(80): 12016-12019 (Journal)
- Registered Authors
- Astin, Jonathan
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/pharmacology*
- Cell Line, Tumor
- Cell Survival/drug effects
- Cisplatin/pharmacology
- Coordination Complexes/chemistry
- Coordination Complexes/pharmacology*
- DNA Damage/drug effects*
- Drug Screening Assays, Antitumor
- Hemolysis
- Humans
- Iridium/chemistry*
- Ligands
- Mice
- Oxidation-Reduction
- Reactive Oxygen Species/metabolism*
- Rhodium/chemistry*
- Ruthenium/chemistry
- Structure-Activity Relationship
- Zebrafish
- PubMed
- 31498360 Full text @ Chem. Commun. (Camb.)
Citation
Parveen, S., Hanif, M., Leung, E., Tong, K.K.H., Yang, A., Astin, J., De Zoysa, G.H., Steel, T.R., Goodman, D., Movassaghi, S., Söhnel, T., Sarojini, V., Jamieson, S.M.F., Hartinger, C.G. (2019) Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity. Chemical communications (Cambridge, England). 55(80):12016-12019.
Abstract
Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS-mediated stress pathways.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping