PUBLICATION
Active behaviour during early development shapes glucocorticoid reactivity
- Authors
- Castillo-Ramírez, L.A., Ryu, S., De Marco, R.J.
- ID
- ZDB-PUB-190907-4
- Date
- 2019
- Source
- Scientific Reports 9: 12796 (Journal)
- Registered Authors
- Ryu, Soojin
- Keywords
- none
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian/metabolism
- Glucocorticoids/metabolism*
- Reflex, Startle
- Stress, Physiological
- Swimming
- Zebrafish/embryology*
- Zebrafish/metabolism
- PubMed
- 31488853 Full text @ Sci. Rep.
Citation
Castillo-Ramírez, L.A., Ryu, S., De Marco, R.J. (2019) Active behaviour during early development shapes glucocorticoid reactivity. Scientific Reports. 9:12796.
Abstract
Glucocorticoids are the final effectors of the stress axis, with numerous targets in the central nervous system and the periphery. They are essential for adaptation, yet currently it is unclear how early life events program the glucocorticoid response to stress. Here we provide evidence that involuntary swimming at early developmental stages can reconfigure the cortisol response to homotypic and heterotypic stress in larval zebrafish (Danio rerio), also reducing startle reactivity and increasing spontaneous activity as well as energy efficiency during active behaviour. Collectively, these data identify a role of the genetically malleable zebrafish for linking early life stress with glucocorticoid function in later life.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping