PUBLICATION
Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene
- Authors
- Hussein, E.A., Zagho, M.M., Rizeq, B.R., Younes, N.N., Pintus, G., Mahmoud, K.A., Nasrallah, G.K., Elzatahry, A.A.
- ID
- ZDB-PUB-190817-5
- Date
- 2019
- Source
- International Journal of Nanomedicine 14: 4529-4539 (Journal)
- Registered Authors
- Nasrallah, Gheyath
- Keywords
- MCF7, MXene, acute toxicity, gold, magnetite, photothermal therapy
- MeSH Terms
-
- Animals
- Cell Survival/drug effects
- Embryo, Nonmammalian/drug effects
- Humans
- Hyperthermia, Induced*
- MCF-7 Cells
- Nanocomposites/therapeutic use*
- Nanocomposites/ultrastructure
- Phototherapy*
- Teratogens/toxicity
- Titanium/chemistry*
- Toxicity Tests, Acute*
- X-Ray Diffraction
- Zebrafish
- PubMed
- 31417256 Full text @ Int. J. Nanomedicine
Citation
Hussein, E.A., Zagho, M.M., Rizeq, B.R., Younes, N.N., Pintus, G., Mahmoud, K.A., Nasrallah, G.K., Elzatahry, A.A. (2019) Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene. International Journal of Nanomedicine. 14:4529-4539.
Abstract
Purpose: Here, we fabricated two plasmonic 2D Ti3C2Tx-based nanocomposites (Au/MXene and Au/Fe3O4/MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene. Methods: Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH4 on Ti3C2Tx flakes. For targeted PTT, magnetic Au/Fe3O4/MXene was synthesized via a reaction between freshly prepared magnetite Fe3O4 NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs). Results: Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/Fe3O4/MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/Fe3O4/MXene had less embryonic mortality (LC50 ≫ 1000 µg/mL) than pure MXene (LC50=257.46 µg/mL). Conclusion: Our new Au/MXene and Au/Fe3O4/MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping