PUBLICATION
Anterior Trunk Muscle Shows Mix of Axial and Appendicular Developmental Patterns
- Authors
- Sagarin, K.A., Redgrave, A.C., Mosimann, C., Burke, A.C., Devoto, S.H.
- ID
- ZDB-PUB-190808-2
- Date
- 2019
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 248(10): 961-968 (Journal)
- Registered Authors
- Devoto, Stephen Henri, Mosimann, Christian
- Keywords
- Posterior hypaxial muscle, lateral plate mesoderm, migratory muscle precursors, pectoral fin, sternohyoid
- MeSH Terms
-
- Animals
- Cell Differentiation/physiology
- Cell Movement
- Gene Expression Regulation, Developmental*
- Mesoderm/embryology*
- Muscle, Skeletal/anatomy & histology*
- Muscle, Skeletal/embryology
- Muscle, Skeletal/growth & development
- Somites/embryology*
- Zebrafish
- PubMed
- 31386244 Full text @ Dev. Dyn.
Citation
Sagarin, K.A., Redgrave, A.C., Mosimann, C., Burke, A.C., Devoto, S.H. (2019) Anterior Trunk Muscle Shows Mix of Axial and Appendicular Developmental Patterns. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(10):961-968.
Abstract
Background Skeletal muscle in the trunk derives from the somites, paired segments of paraxial mesoderm. Whereas axial musculature develops within the somite, appendicular muscle develops following migration of muscle precursors into lateral plate mesoderm. The development of muscles bridging axial and appendicular systems appears mixed.
Results We examine development of three migratory muscle precursor-derived muscles in zebrafish: the sternohyoideus (SH), pectoral fin (PF), and posterior hypaxial (PHM) muscles. We show there is an anterior to posterior gradient to the developmental gene expression and maturation of these three muscles. Sternohyoideus muscle precursors exhibit a long delay between migration and differentiation, pectoral fin muscle precursors exhibit a moderate delay in differentiation, and posterior hypaxial muscle precursors show virtually no delay between migration and differentiation. Using lineage tracing, we show that lateral plate contribution to the posterior hypaxial muscle is minor, unlike its known extensive contribution to the pectoral fin muscle and absence in the ventral extension of axial musculature.
Conclusions We propose that PHM development is intermediate between a migratory muscle mode and an axial muscle mode of development, wherein the PHM differentiates after a very short migration of its precursors and becomes more anterior primarily by elongation of differentiated muscle fibers. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping