PUBLICATION
A critical review of zebrafish schizophrenia models: time for validation?
- Authors
- Gawel, K., Banono, N.S., Michalak, A., Esguerra, C.V.
- ID
- ZDB-PUB-190807-11
- Date
- 2019
- Source
- Neuroscience and biobehavioral reviews 107: 6-22 (Review)
- Registered Authors
- Banono, Nancy, Esguerra, Camila V., Gawel, Kinga Aurelia
- Keywords
- drugs, models, risk genes, schizophrenia, validation, zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Schizophrenia*
- Zebrafish*
- PubMed
- 31381931 Full text @ Neurosci. Biobehav. Rev.
Citation
Gawel, K., Banono, N.S., Michalak, A., Esguerra, C.V. (2019) A critical review of zebrafish schizophrenia models: time for validation?. Neuroscience and biobehavioral reviews. 107:6-22.
Abstract
Schizophrenia is a mental disorder that affects 1% of the population worldwide and is manifested as a broad spectrum of symptoms, from hallucinations to memory impairment. It is believed that genetic and/or environmental factors may contribute to the occurrence of this disease. Recently, the zebrafish has emerged as a valuable and attractive model for various neurological disorders including schizophrenia. In this review, we describe current pharmacological models of schizophrenia with special emphasis on providing insights into the pros and cons of using zebrafish as a behavioural model of this disease. Moreover, we highlight the advantages and utility of using zebrafish for elucidating the genetic mechanisms underlying this psychiatric disorder. We believe that the zebrafish has high potential also in the area of precision medicine and may complement the development of therapeutics, especially for pharmacoresistant patients.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping