Two Compounds Isolated From Ganglioside GM1 Promote Angiogenesis in Zebrafish
- Shi, Y., Wang, X., Shi, Y., Zhang, J., Zhao, S., Yin, Z., Xu, G., Duan, X., Guo, Z., Liang, X., Liu, D.
- Journal of Cardiovascular Pharmacology 74: 71-79 (Journal)
- Registered Authors
- Liu, Dong, Shi, Yunwei, Yin, Zhenhua
- MeSH Terms
- Angiogenesis Inducing Agents/pharmacology*
- Angiogenesis Inducing Agents/toxicity
- Animals, Genetically Modified
- Cell Differentiation/drug effects
- Cell Movement/drug effects
- Cell Proliferation/drug effects
- Embryo, Nonmammalian/blood supply*
- Endothelial Cells/drug effects*
- Endothelial Cells/metabolism
- G(M1) Ganglioside/pharmacology*
- G(M1) Ganglioside/toxicity
- Gene Expression Regulation, Developmental
- Neovascularization, Physiologic/drug effects*
- Receptors, Notch/genetics
- Receptors, Notch/metabolism
- Signal Transduction
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- 31274845 Full text @ J. Cardiovasc. Pharmacol.
Shi, Y., Wang, X., Shi, Y., Zhang, J., Zhao, S., Yin, Z., Xu, G., Duan, X., Guo, Z., Liang, X., Liu, D. (2019) Two Compounds Isolated From Ganglioside GM1 Promote Angiogenesis in Zebrafish. Journal of Cardiovascular Pharmacology. 74:71-79.
Ganglioside has been implicated to play important roles in modulating various cell signaling and biological functions. However, the functional analysis of a single ganglioside in a zebrafish model is so far lacking. In this study, we investigated the angiogenic effects of 2 monosialoganglioside compounds isolated from GM1 in zebrafish embryos. First, we showed the tested compounds are adequate safe. Then, we found that these compounds exhibited significant proangiogenic effect through enhancement of endothelial cell proliferation, migration, and differentiation. Furthermore, the 2 compounds were proved to promote angiogenesis through, at least partially, modulating the level of Notch signaling. This study provides the novel insights into the clinical application of the 2 ganglioside compounds and GM1.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes