ZFIN ID: ZDB-PUB-190604-9
Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)
Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H.
Date: 2019
Source: Chemosphere   232: 171-179 (Journal)
Registered Authors: Lu, Huiqiang
Keywords: Hepatotoxicity, Metabolism disorder, Oxidative stress, Tricyclazole, Zebrafish
MeSH Terms:
  • Animals
  • Antioxidants/metabolism
  • Apoptosis
  • Chemical and Drug Induced Liver Injury
  • Oxidative Stress
  • Reactive Oxygen Species/metabolism
  • Thiazoles/toxicity*
  • Water Pollutants, Chemical/toxicity*
  • Zebrafish/metabolism
PubMed: 31154177 Full text @ Chemosphere
ABSTRACT
Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function.
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