ZFIN ID: ZDB-PUB-190601-16
Neuronal Architecture of a Visual Center that Processes Optic Flow
Kramer, A., Wu, Y., Baier, H., Kubo, F.
Date: 2019
Source: Neuron   103(1): 118-132.e7 (Journal)
Registered Authors: Baier, Herwig, Kramer, Anna, Kubo, Fumi, Wu, Yunmin
Keywords: FuGIMA, PA-GFP, direction-selective retinal ganglion cells, nls-GCaMP, optic flow, optokinetic response, optomotor response, paGFP, pretectum, zebrafish
MeSH Terms:
  • Animals
  • Cerebellum/cytology
  • Cerebellum/physiology
  • Dendrites/physiology
  • Neuropil/physiology
  • Neuropil/ultrastructure
  • Optic Flow/physiology*
  • Presynaptic Terminals/physiology
  • Reticular Formation/cytology
  • Reticular Formation/physiology
  • Retinal Ganglion Cells/physiology
  • Superior Colliculi/cytology
  • Superior Colliculi/physiology
  • Vision, Binocular/physiology
  • Vision, Monocular/physiology
  • Visual Pathways/anatomy & histology
  • Visual Pathways/cytology*
  • Zebrafish/physiology
PubMed: 31147153 Full text @ Neuron
Animals use global image motion cues to actively stabilize their position by compensatory movements. Neurons in the zebrafish pretectum distinguish different optic flow patterns, e.g., rotation and translation, to drive appropriate behaviors. Combining functional imaging and morphological reconstruction of single cells, we revealed critical neuroanatomical features of this sensorimotor transformation. Terminals of direction-selective retinal ganglion cells (DS-RGCs) are located within the pretectal retinal arborization field 5 (AF5), where they meet dendrites of pretectal neurons with simple tuning to monocular optic flow. Translation-selective neurons, which respond selectively to optic flow in the same direction for both eyes, are intermingled with these simple cells but do not receive inputs from DS-RGCs. Mutually exclusive populations of pretectal projection neurons innervate either the reticular formation or the cerebellum, which in turn control motor responses. We posit that local computations in a defined pretectal circuit transform optic flow signals into neural commands driving optomotor behavior.