PUBLICATION
Sex differences in behavior and neuropharmacology of zebrafish
- Authors
- Genario, R., de Abreu, M.S., Giacomini, A.C.V.V., Demin, K.A., Kalueff, A.V.
- ID
- ZDB-PUB-190516-19
- Date
- 2019
- Source
- The European journal of neuroscience 52(1): 2586-2603 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- CNS diseases, gender differences, pharmacogenetics, sex-environment interactions
- MeSH Terms
-
- Animals
- Behavior, Animal
- Disease Models, Animal
- Female
- Male
- Neuropharmacology
- Neurosciences*
- Sex Characteristics
- Zebrafish*
- PubMed
- 31090957 Full text @ Eur. J. Neurosci.
Citation
Genario, R., de Abreu, M.S., Giacomini, A.C.V.V., Demin, K.A., Kalueff, A.V. (2019) Sex differences in behavior and neuropharmacology of zebrafish. The European journal of neuroscience. 52(1):2586-2603.
Abstract
Sex is an important variable in biomedical research. The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in translational neuroscience and pharmacology. Mounting evidence indicates important sex differences in zebrafish behavioral and neuropharmacological responses. Here, we discuss the role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of sex differences, fostering future CNS drug discovery and the search for novel sex-specific therapies. Finally, we highlight the interplay between sex and environment in zebrafish models of sex-environment correlations as an important strategy of CNS disease modeling using this aquatic organism. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping