PUBLICATION
Enhanced effects of curcumin encapsulated in polycaprolactone-grafted oligocarrageenan nanomicelles, a novel nanoparticle drug delivery system
- Authors
- Youssouf, L., Bhaw-Luximon, A., Diotel, N., Catan, A., Giraud, P., Gimié, F., Koshel, D., Casale, S., Bénard, S., Meneyrol, V., Lallemand, L., Meilhac, O., Lefebvre D'Hellencourt, C., Jhurry, D., Couprie, J.
- ID
- ZDB-PUB-190514-1
- Date
- 2019
- Source
- Carbohydrate Polymers 217: 35-45 (Journal)
- Registered Authors
- Diotel, Nicolas
- Keywords
- Curcumin, Drug delivery, Endothelial cells, Graft-copolymer, Inflammation, Nanomicelles
- MeSH Terms
-
- Acetylation
- Animals
- Anti-Inflammatory Agents, Non-Steroidal/chemistry
- Anti-Inflammatory Agents, Non-Steroidal/pharmacology*
- Carrageenan/chemistry
- Carrageenan/isolation & purification
- Cell Line
- Curcumin/chemistry
- Curcumin/pharmacology*
- Drug Carriers/chemical synthesis
- Drug Carriers/chemistry*
- Drug Carriers/toxicity
- Drug Liberation
- Female
- Gammaproteobacteria/enzymology
- Glycoside Hydrolases/chemistry
- Glycoside Hydrolases/isolation & purification
- Humans
- Hydrolysis
- Male
- Mice, Inbred C57BL
- Micelles*
- Oligosaccharides/chemical synthesis
- Oligosaccharides/chemistry*
- Oligosaccharides/isolation & purification
- Oligosaccharides/toxicity
- Oxazines/chemistry
- Particle Size
- Polyesters/chemical synthesis
- Polyesters/chemistry*
- Polyesters/toxicity
- Rhodophyta/chemistry
- Rifampin/chemistry
- Zebrafish
- PubMed
- 31079683 Full text @ Carbohydr. Polym.
Citation
Youssouf, L., Bhaw-Luximon, A., Diotel, N., Catan, A., Giraud, P., Gimié, F., Koshel, D., Casale, S., Bénard, S., Meneyrol, V., Lallemand, L., Meilhac, O., Lefebvre D'Hellencourt, C., Jhurry, D., Couprie, J. (2019) Enhanced effects of curcumin encapsulated in polycaprolactone-grafted oligocarrageenan nanomicelles, a novel nanoparticle drug delivery system. Carbohydrate Polymers. 217:35-45.
Abstract
One of the most effective strategies to enhance the bioavailability and the therapeutic effect of hydrophobic drugs is the use of nanocarriers. We have used κ-carrageenan extracted from Kappaphycus alvarezii to produce oligocarrageenan via an enzymatic degradation process. Polycaprolactone (PCL) chains were grafted onto the oligocarrageenans using a protection/deprotection technique yielding polycaprolactone-grafted oligocarrageenan. The resulting amphiphilic copolymers formed spherical nanomicelles with a mean size of 187 ± 21 nm. Hydrophobic drugs such as curcumin were efficiently encapsulated in the micelles and released within 24-72 h in solution. The micelles were non-cytotoxic and facilitated the uptake of curcumin by endothelial EA-hy926 cells. They also increased the anti-inflammatory effect of curcumin in TNF-alpha-induced inflammation experiments. Finally, in vivo experiments supported a lack of toxicity in zebrafish and thus the potential use of polycaprolactone-grafted oligocarrageenan to improve the delivery of hydrophobic compounds to different organs, including liver, lung and brain as shown in mice.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping