The Zebrafish: A Research Model To Understand The Evolution Of Vertebrate Immunity
- García-Moreno, D., Tyrkalska, S.D., Valera-Pérez, A., Gómez-Abenza, E., Pérez Oliva, A.B., Mulero, V.
- Fish & shellfish immunology 90: 215-222 (Review)
- Registered Authors
- Mulero, Victor
- MeSH Terms
- Biological Evolution*
- Disease Models, Animal
- Evolution, Molecular
- Fish Proteins/genetics*
- Fish Proteins/metabolism
- Immunity, Innate*/genetics
- Models, Animal
- Receptors, Immunologic/genetics*
- Receptors, Immunologic/metabolism
- 31039438 Full text @ Fish Shellfish Immunol.
García-Moreno, D., Tyrkalska, S.D., Valera-Pérez, A., Gómez-Abenza, E., Pérez Oliva, A.B., Mulero, V. (2019) The Zebrafish: A Research Model To Understand The Evolution Of Vertebrate Immunity. Fish & shellfish immunology. 90:215-222.
The zebrafish has unique advantages for understanding the evolution of vertebrate immunity and to model human diseases. In this review, we will firstly give an overview of the current knowledge on vertebrate innate immune receptors with special emphasis on the inflammasome and then summarize the main contribution of the zebrafish model to this field, including to the identification of novel inflammasome components and to the mechanisms involved in its activation, assembly and clearance of intracellular bacteria.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes