PUBLICATION

Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model

Authors
Ahmad, O., Wang, B., Ma, K., Deng, Y., Li, M., Yang, L., Yang, Y., Zhao, J., Cheng, L., Zhou, Q., Shang, J.
ID
ZDB-PUB-190426-1
Date
2019
Source
International Journal of Molecular Sciences   20(8): (Journal)
Registered Authors
Li, Maoru, Shang, Jing, Wang, Bing
Keywords
Gastrodin, larval zebrafish, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis
MeSH Terms
  • Animals
  • Antioxidants/isolation & purification
  • Antioxidants/therapeutic use*
  • Benzyl Alcohols/isolation & purification
  • Benzyl Alcohols/therapeutic use*
  • Disease Models, Animal
  • Gastrodia/chemistry*
  • Gene Expression Regulation/drug effects
  • Glucosides/isolation & purification
  • Glucosides/therapeutic use*
  • Larva/drug effects
  • Larva/genetics
  • Larva/metabolism
  • Lipid Metabolism/drug effects*
  • Non-alcoholic Fatty Liver Disease/drug therapy*
  • Non-alcoholic Fatty Liver Disease/genetics
  • Non-alcoholic Fatty Liver Disease/metabolism
  • Non-alcoholic Fatty Liver Disease/pathology
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed
31018538 Full text @ Int. J. Mol. Sci.
Abstract
Non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the world. However, there are still no drugs for NAFLD/NASH in the market. Gastrodin (GAS) is a bioactive compound that is extracted from Gastrodia elata, which is used as an active compound on nervous system diseases. Recent reports showed that GAS and Gastrodia elata possess anti-oxidant activity and lipid regulating effects, which makes us curious to reveal the anti-NAFLD effect of GAS. A high cholesterol diet (HCD) was used to induce a NAFLD larval zebrafish model, and the lipid regulation and anti-oxidant effects were tested on the model. Furthermore, qRT-PCR studied the underlying mechanism of GAS. To conclude, this study revealed a lipid regulation and anti-oxidant insights of GAS on NAFLD larval zebrafish model and provided a potential therapeutic compound for NAFLD treatment.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping