PUBLICATION
Regulation of lipid rafts, angiogenesis and inflammation by AIBP
- Authors
- Fang, L., Miller, Y.I.
- ID
- ZDB-PUB-190416-12
- Date
- 2019
- Source
- Current opinion in lipidology 30(3): 218-223 (Journal)
- Registered Authors
- Fang, Longhou, Miller, Yury
- Keywords
- none
- MeSH Terms
-
- Animals
- Atherosclerosis/metabolism
- Cholesterol/metabolism
- Humans
- Inflammation/metabolism
- Membrane Microdomains/metabolism*
- Neovascularization, Physiologic*
- Phosphoproteins/metabolism*
- PubMed
- 30985364 Full text @ Curr. Opin. Lipidol.
Citation
Fang, L., Miller, Y.I. (2019) Regulation of lipid rafts, angiogenesis and inflammation by AIBP. Current opinion in lipidology. 30(3):218-223.
Abstract
Purpose of review Recent studies demonstrate an important role of the secreted apolipoprotein A-I binding protein (AIBP) in regulation of cholesterol efflux and lipid rafts. The article discusses these findings in the context of angiogenesis and inflammation.
Recent findings Lipid rafts are cholesterol-rich and sphingomyelin-rich membrane domains in which many receptor complexes assemble upon activation. AIBP mediates selective cholesterol efflux, in part via binding to toll-like receptor-4 (TLR4) in activated macrophages and microglia, and thus reverses lipid raft increases in activated cells. Recent articles report AIBP regulation of vascular endothelial growth factor receptor-2, Notch1 and TLR4 function. In zebrafish and mouse animal models, AIBP deficiency results in accelerated angiogenesis, increased inflammation and exacerbated atherosclerosis. Spinal delivery of recombinant AIBP reduces neuraxial inflammation and reverses persistent pain state in a mouse model of chemotherapy-induced polyneuropathy. Inhalation of recombinant AIBP reduces lipopolysaccharide-induced acute lung injury in mice. These findings are discussed in the perspective of AIBP's proposed other function, as an NAD(P)H hydrate epimerase, evolving into a regulator of cholesterol trafficking and lipid rafts.
Summary Novel findings of AIBP regulatory circuitry affecting lipid rafts and related cellular processes may provide new therapeutic avenues for angiogenic and inflammatory diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping