PUBLICATION
Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1
- Authors
- Chowdhury, T.A., Li, K., Ramchandran, R.
- ID
- ZDB-PUB-190327-2
- Date
- 2019
- Source
- Vascular Pharmacology 114: 103-109 (Review)
- Registered Authors
- Li, Keguo, Ramchandran, Ramani
- Keywords
- Angiogenesis, CRISPRi, Dll4, Endothelial cells, Morpholinos, Tie1, Vascular, Zebrafish
- MeSH Terms
-
- Animals
- Body Patterning
- Gene Expression Regulation
- Gene Expression Regulation, Developmental
- Humans
- Intercellular Signaling Peptides and Proteins/genetics*
- Intercellular Signaling Peptides and Proteins/metabolism
- Intracellular Signaling Peptides and Proteins/genetics
- Intracellular Signaling Peptides and Proteins/metabolism
- Models, Animal
- Neovascularization, Physiologic/genetics*
- RNA, Long Noncoding/genetics*
- RNA, Long Noncoding/metabolism
- Receptor, TIE-1/genetics*
- Receptor, TIE-1/metabolism
- Signal Transduction
- Vascular Remodeling/genetics*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 30910126 Full text @ Vascul. Pharmacol.
Citation
Chowdhury, T.A., Li, K., Ramchandran, R. (2019) Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1. Vascular Pharmacology. 114:103-109.
Abstract
Pervasive transcription is a feature of the human genome that requires better understanding. Over the last decade or so, RNA species longer than 200 nucleotides-dubbed long non-coding RNA (lncRNAs)-had been found in sense or anti-sense orientation within or outside of genes that encode proteins. Importantly, lncRNA-mediated gene regulation and the elements that control lncRNA expression are a source of fascination among molecular biologists. In vascular biology, a dozen or so lncRNAs had been identified, and progress occurs each day. In this review, we highlighted our laboratories' contribution to the lncRNA field by discussing lessons learned from two lncRNAs in the tyrosine kinase containing immunoglobulin and epidermal growth factor homology1 (Tie1) and delta-like 4 (Dll4) loci. These genes are responsible for basic vascular patterning and pathophysiological remodeling in angiogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping