PUBLICATION
Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models
- Authors
- Zhu, X.Y., Guo, D.W., Lao, Q.C., Xu, Y.Q., Meng, Z.K., Xia, B., Yang, H., Li, C.Q., Li, P.
- ID
- ZDB-PUB-190316-5
- Date
- 2019
- Source
- Scientific Reports 9: 4541 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents/pharmacology*
- Apoptosis
- Breast Neoplasms/drug therapy*
- Breast Neoplasms/pathology
- Cell Proliferation
- Drug Resistance, Neoplasm/drug effects*
- Drug Synergism*
- Female
- Furans/pharmacology*
- Heterocyclic Compounds, 2-Ring/pharmacology*
- Humans
- Lung Neoplasms/drug therapy*
- Lung Neoplasms/pathology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
- Zebrafish
- PubMed
- 30872660 Full text @ Sci. Rep.
Citation
Zhu, X.Y., Guo, D.W., Lao, Q.C., Xu, Y.Q., Meng, Z.K., Xia, B., Yang, H., Li, C.Q., Li, P. (2019) Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Scientific Reports. 9:4541.
Abstract
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. In this study, we have successfully established zebrafish xenografts with 5 various human cancer cell lines; and validated these models with anti-cancer drugs used clinically for treating human cancer patients. We found that Furanodiene was therapeutically effective for human JF 305 pancreatic cancer cells and MCF-7 breast cancer cells xenotranplanted into zebrafish. Furanodiene showed a markedly synergistic anti-cancer effect when used in combination with 5-FU (5-Fluorouracil) for both human breast cancer MDA-MB-231 cells and human liver cancer BEL-7402 cells xenotransplanted into zebrafish. Unexpectedly, Furanodiene reversed multiple drug resistance in the zebrafish xenotransplanted with cis-Platinum-resistant human non-small cell lung cancer cells and Adriamycin-resistant human breast cancer cells. Furanodiene played its anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level, but no effect on Pgp related gene (MDR1) expression. These results suggest sensitizition and synergistic anti-cancer effects of Furanodiene that is worthy of a further investigation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping