ZFIN ID: ZDB-PUB-190314-2
Development of the brain vasculature and the blood-brain barrier in zebrafish
Quiñonez-Silvero, C., Hübner, K., Herzog, W.
Date: 2019
Source: Developmental Biology   457(2): 181-190 (Review)
Registered Authors: Herzog, Wiebke
Keywords: Angiogenesis, Central nervous system, Junctions, Neurovascular unit
MeSH Terms:
  • Animals
  • Blood-Brain Barrier/embryology*
  • Brain/blood supply*
  • Brain/embryology
  • Cardiovascular System/embryology*
  • Endothelial Cells/physiology
  • Endothelium, Vascular/embryology
  • Endothelium, Vascular/physiology
  • Neovascularization, Physiologic/physiology*
  • Tight Junctions/physiology
  • Zebrafish/embryology*
PubMed: 30862465 Full text @ Dev. Biol.
To ensure tissue homeostasis the brain needs to be protected from blood-derived fluctuations or pathogens that could affect its function. Therefore, the brain capillaries develop tissue-specific properties to form a selective blood-brain barrier (BBB), allowing the passage of essential molecules to the brain and blocking the penetration of potentially harmful compounds or cells. Previous studies reported the presence of this barrier in zebrafish. The intrinsic features of the zebrafish embryos and larvae in combination with optical techniques, make them suitable for the study of barrier establishment and maturation. In this review, we discuss the most recent contributions to the development and formation of a functional zebrafish BBB. Moreover, we compare the molecular and cellular characteristic of the zebrafish and the mammalian BBB.