PUBLICATION
Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
- Authors
- Yang, J., Zhang, P., Hu, Y., Liu, T., Sun, J., Wang, X.
- ID
- ZDB-PUB-190302-1
- Date
- 2019
- Source
- Journal of enzyme inhibition and medicinal chemistry 34: 651-656 (Journal)
- Registered Authors
- Keywords
- 3-Arylcoumarin, Alzheimer’s disease, antioxidant activity, cholinesterase inhibitors, monoamine oxidase inhibitors
- MeSH Terms
-
- Acetylcholinesterase/metabolism*
- Alzheimer Disease/drug therapy*
- Alzheimer Disease/metabolism
- Animals
- Antioxidants/chemical synthesis
- Antioxidants/chemistry
- Antioxidants/pharmacology*
- Cholinesterase Inhibitors/chemical synthesis
- Cholinesterase Inhibitors/chemistry
- Cholinesterase Inhibitors/pharmacology*
- Coumarins/chemical synthesis
- Coumarins/chemistry
- Coumarins/pharmacology*
- Dose-Response Relationship, Drug
- Molecular Structure
- Monoamine Oxidase/metabolism*
- Monoamine Oxidase Inhibitors/chemical synthesis
- Monoamine Oxidase Inhibitors/chemistry
- Monoamine Oxidase Inhibitors/pharmacology*
- Rats, Wistar
- Structure-Activity Relationship
- Zebrafish
- PubMed
- 30746966 Full text @ J Enzyme Inhib Med Chem
Citation
Yang, J., Zhang, P., Hu, Y., Liu, T., Sun, J., Wang, X. (2019) Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents. Journal of enzyme inhibition and medicinal chemistry. 34:651-656.
Abstract
Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping