PUBLICATION
Zebrafish models for attention deficit hyperactivity disorder (ADHD)
- Authors
- Fontana, B.D., Franscescon, F., Rosemberg, D.B., Norton, W.H.J., Kalueff, A.V., Parker, M.O.
- ID
- ZDB-PUB-190220-7
- Date
- 2019
- Source
- Neuroscience and biobehavioral reviews 100: 9-18 (Review)
- Registered Authors
- Kalueff, Allan V., Norton, Will
- Keywords
- ADHD, behavior, dopamine, genetics, noradrenaline, serotonin., zebrafish
- MeSH Terms
-
- Animals
- Attention Deficit Disorder with Hyperactivity/genetics*
- Attention Deficit Disorder with Hyperactivity/physiopathology*
- Behavior, Animal
- Brain/physiopathology*
- Disease Models, Animal*
- Translational Research, Biomedical*
- Zebrafish/genetics
- PubMed
- 30779935 Full text @ Neurosci. Biobehav. Rev.
Citation
Fontana, B.D., Franscescon, F., Rosemberg, D.B., Norton, W.H.J., Kalueff, A.V., Parker, M.O. (2019) Zebrafish models for attention deficit hyperactivity disorder (ADHD). Neuroscience and biobehavioral reviews. 100:9-18.
Abstract
Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing rodent models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping