PUBLICATION
Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2
- Authors
- Dalla Vecchia, E., Mortimer, N., Palladino, V.S., Kittel-Schneider, S., Lesch, K.P., Reif, A., Schenck, A., Norton, W.H.J.
- ID
- ZDB-PUB-190212-11
- Date
- 2019
- Source
- Psychiatric genetics 29: 1-17 (Review)
- Registered Authors
- Norton, Will
- Keywords
- none
- MeSH Terms
-
- Autism Spectrum Disorder/physiopathology*
- Membrane Proteins/metabolism
- Animals
- Nerve Tissue Proteins/metabolism
- Disease Models, Animal
- Drosophila
- Ubiquitin-Protein Ligases/metabolism
- Mice
- Models, Biological
- Zebrafish
- Attention Deficit Disorder with Hyperactivity/physiopathology*
- Humans
- Receptors, G-Protein-Coupled/metabolism
- PubMed
- 30376466 Full text @ Psychiatr. Genet.
Citation
Dalla Vecchia, E., Mortimer, N., Palladino, V.S., Kittel-Schneider, S., Lesch, K.P., Reif, A., Schenck, A., Norton, W.H.J. (2019) Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2. Psychiatric genetics. 29:1-17.
Abstract
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients - CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system. By bringing together behavioral and neurobiological data, we demonstrate how a cross-species approach can provide integrated insights into gene function and the pathogenesis of ADHD and ASD. The knowledge gained from transgenic models will be essential to discover and validate new treatment targets for these disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping