PUBLICATION
Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish
- Authors
- Lee, S., Kim, C., Shin, H., Kho, Y., Choi, K.
- ID
- ZDB-PUB-190115-5
- Date
- 2019
- Source
- Chemosphere 221: 115-123 (Journal)
- Registered Authors
- Choi, Kyungho
- Keywords
- Alternative chemical, Bisphenol A, Endocrine disruption, Fish, Thyroid regulation
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/pharmacology*
- Cyclohexanes/pharmacology
- Endocrine Disruptors/pharmacology
- Humans
- Larva/drug effects*
- Larva/metabolism
- Phenols/pharmacology*
- Sulfones/pharmacology
- Thyroid Hormones/metabolism*
- Thyroxine/drug effects
- Triiodothyronine/drug effects
- Zebrafish/embryology
- Zebrafish/metabolism*
- PubMed
- 30639807 Full text @ Chemosphere
- CTD
- 30639807
Citation
Lee, S., Kim, C., Shin, H., Kho, Y., Choi, K. (2019) Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish. Chemosphere. 221:115-123.
Abstract
Several structural analogues of bisphenol A (BPA), e.g., bisphenol F (BPF), bisphenol S (BPS), and bisphenol Z (BPZ), have been used as its substitutes in many applications and consequently detected in the environment, and human specimen such as urine and serum. While BPA has been frequently reported for thyroid hormone disruption in both experimental and epidemiological studies, less is known for the BPA analogues. In the present study, thyroid hormone disrupting effects of BPF, BPS and BPZ, were investigated, and compared with those of BPA, using embryo-larval zebrafish (Danio rerio). At 120 hpf, significant increases in T3 and/or T4 were observed in the larval fish following exposure to BPA, BPF, or BPS. Moreover, transcriptional changes of the genes related to thyroid development (hhex and tg), thyroid hormone transport (ttr) and metabolism (ugt1ab) were observed as well. Thyroid hormone (T4) disruption by BPF was observed even at the concentration (2.0 mg/L) lower than the effective concentration determined for BPA (>2.0 mg/L). Delayed hatching was observed by all tested bisphenols. Our results clearly show that these BPA analogues can disrupt thyroid function of the larval fish, and their thyroid hormone disruption potencies could be even greater than that of BPA. The concentrations which disrupt thyroid function of the larval fish were orders of magnitude higher than those occurring in the ambient environment. However, thyroid hormone disruption by longer term exposure and its consequences in the fish population, deserve further investigation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping