PUBLICATION

A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa

Authors
Tu, Y.B., Xiao, T., Gong, G.Y., Bian, Y.Q., Li, Y.F.
ID
ZDB-PUB-190115-1
Date
2019
Source
Natural Product Research   34(7): 981-987 (Journal)
Registered Authors
Xiao, Tong
Keywords
Millettia pachycarpa, anti-inflammatory activity, cytotoxicity, isoflavone
MeSH Terms
  • Animals
  • Anti-Inflammatory Agents/isolation & purification*
  • Anti-Inflammatory Agents/pharmacology
  • Humans
  • Isoflavones/chemistry
  • Isoflavones/isolation & purification*
  • Isoflavones/pharmacology
  • Lipopolysaccharides
  • Macrophages/drug effects
  • Mice
  • Millettia/chemistry*
  • Nitric Oxide/biosynthesis
  • RAW 264.7 Cells
  • Seeds/chemistry*
  • Zebrafish
PubMed
30636441 Full text @ Nat. Prod. Res.
Abstract
A new isoflavone, milletenol A (1), along with four known flavonoids (2-5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4-stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes