PUBLICATION

Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain

Authors
Ma, F., Dong, Z., Berberoglu, M.A.
ID
ZDB-PUB-190113-18
Date
2019
Source
Gene expression patterns : GEP   31: 32-41 (Journal)
Registered Authors
Berberoglu, Michael, Dong, Zhiqiang
Keywords
Adult zebrafish brain, Dc region, Dm region, Dorsal telencephalon, Rbfox RNA-binding proteins, Rbfox2
MeSH Terms
  • Telencephalon/cytology
  • Telencephalon/metabolism*
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
  • Purkinje Cells/metabolism*
  • Zebrafish
  • RNA-Binding Proteins/genetics*
  • RNA-Binding Proteins/metabolism
  • Animals
(all 9)
PubMed
30634066 Full text @ Gene Expr. Patterns
Abstract
Rbfox RNA-binding proteins are expressed in the adult mammalian brain and are required for proper brain development and function. Studies in mice and humans have implicated Rbfox1/RBFOX1 in autism, neuronal excitation and epilepsy, and Rbfox2/RBFOX2 in cerebellar development. The zebrafish has emerged as a prominent model system for brain study, possessing neuroanatomical conservation with mammals and an extensive capacity for adult neurogenesis and plasticity. In this study, we characterize Rbfox1l and Rbfox2 expression in the adult zebrafish brain. While Rbfox2 is expressed broadly, Rbfox1l is expressed in restricted populations of neurons in the dorsal telencephalon and cerebellum. In the dorsal telencephalon, Rbfox1l is expressed in a specific population of neurons spanning Dm and Dc regions. In the cerebellum, Rbfox1l and Rbfox2 are expressed in the Purkinje cell layer, reminiscent of Rbfox1 and Rbfox2 expression in the mammalian cerebellum. Our findings motivate future studies of Rbfox function in the zebrafish brain.
Genes / Markers
Figures
Figure Gallery (7 images)
Show all Figures
Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
No data available
Fish
No data available
Antibodies
Orthology
No data available
Engineered Foreign Genes
No data available
Mapping
No data available
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Citation
Ma, F., Dong, Z., Berberoglu, M.A. (2019) Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain. Gene expression patterns : GEP. 31:32-41.