PUBLICATION

The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling

Authors
Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X.
ID
ZDB-PUB-190107-1
Date
2019
Source
Developmental Biology   446(2): 142-150 (Journal)
Registered Authors
Li, Beibei, Lou, Xin, Yang, Yuxi
Keywords
Neuregulin-ERBB signalling, heart development, ventricle trabeculation, zebrafish, zfpm1
Datasets
GEO:GSE95118
MeSH Terms
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
  • Cell Proliferation/genetics
  • Receptor, ErbB-2/genetics*
  • Receptor, ErbB-2/metabolism
  • Heart/embryology
  • Gene Expression Regulation, Developmental
  • Cells, Cultured
  • Neuregulins/genetics*
  • Neuregulins/metabolism
  • Signal Transduction/genetics*
  • Gene Knockout Techniques
  • Gene Expression Profiling
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Animals
  • Myocytes, Cardiac/cytology
  • Myocytes, Cardiac/metabolism
  • Microscopy, Confocal
  • Myocardium/cytology
  • Myocardium/metabolism*
  • Animals, Genetically Modified
(all 23)
PubMed
30611731 Full text @ Dev. Biol.
Abstract
Ventricular trabeculation is one essential step for generating a functionally competent ventricular wall, while how the early trabeculae carneae forms and subsequently develops into mature chambers is poorly understood. We found that in zebrafish zfpm1-/- juvenile, cardiac function is significantly compromised, with hearts exhibiting deformed trabecular meshwork. To elucidate the mechanisms of Zfpm1 function in cardiac trabeculation, we analyzed zfpm1 mutant hearts more closely and found that loss of Zfpm1 activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation during cardiac trabeculae growth and modeling stages. These results implicate Zfpm1 plays a pivotal role in coordinating trabeculae patterning and growth.
Genes / Markers
Figures
Figure Gallery (8 images)
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
nju205GtTransgenic Insertion
s843TgTransgenic Insertion
    twu34TgTransgenic Insertion
      nju204
        		Small Deletion
        nju207
          		Small Deletion
          nju208
            		Small Deletion
            nju206
              		Small Deletion
              1 - 7 of 7
              Show
              Human Disease / Model
              No data available
              Sequence Targeting Reagents
              Target Reagent Reagent Type
              zfpm1CRISPR11-zfpm1CRISPR
              zfpm2bCRISPR1-zfpm2bCRISPR
              1 - 2 of 2
              Show
              Fish
              Fish
              WT
              zfpm1nju204/nju204
              zfpm1nju204/nju204; s843Tg
              zfpm1nju204/nju204; twu34Tg
              zfpm1nju207/nju207
              zfpm1nju208/nju208
              zfpm2anju205Gt
              zfpm2bnju206/nju206; zfpm2anju205Gt/nju205Gt
              1 - 8 of 8
              Show
              Antibodies
              Orthology
              No data available
              Engineered Foreign Genes
              Marker Marker Type Name
              EGFPEFGEGFP
              GFPEFGGFP
              1 - 2 of 2
              Show
              Mapping
              No data available
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              Citation
              Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150.