PUBLICATION
Coronary Vasculature in Cardiac Development and Regeneration
- Authors
- Kapuria, S., Yoshida, T., Lien, C.L.
- ID
- ZDB-PUB-181220-2
- Date
- 2018
- Source
- Journal of cardiovascular development and disease 5(4): (Journal)
- Registered Authors
- Lien, Ching-Ling (Ellen)
- Keywords
- coronary vessels, endothelial cells, heart regeneration, perivascular cells
- MeSH Terms
- none
- PubMed
- 30563016 Full text @ J Cardiovasc Dev Dis
Citation
Kapuria, S., Yoshida, T., Lien, C.L. (2018) Coronary Vasculature in Cardiac Development and Regeneration. Journal of cardiovascular development and disease. 5(4):.
Abstract
Functional coronary circulation is essential for a healthy heart in warm-blooded vertebrates, and coronary diseases can have a fatal consequence. Despite the growing interest, the knowledge about the coronary vessel development and the roles of new coronary vessel formation during heart regeneration is still limited. It is demonstrated that early revascularization is required for efficient heart regeneration. In this comprehensive review, we first describe the coronary vessel formation from an evolutionary perspective. We further discuss the cell origins of coronary endothelial cells and perivascular cells and summarize the critical signaling pathways regulating coronary vessel development. Lastly, we focus on the current knowledge about the molecular mechanisms regulating heart regeneration in zebrafish, a genetically tractable vertebrate model with a regenerative adult heart and well-developed coronary system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping