PUBLICATION
Endothelial Contributions to Zebrafish Heart Regeneration
- Authors
- Fernandez, C.E., Bakovic, M., Karra, R.
- ID
- ZDB-PUB-181215-15
- Date
- 2018
- Source
- Journal of cardiovascular development and disease 5(4): (Review)
- Registered Authors
- Karra, Ravi
- Keywords
- cardiac regeneration, endothelium, vascular
- MeSH Terms
- none
- PubMed
- 30544906 Full text @ J Cardiovasc Dev Dis
Citation
Fernandez, C.E., Bakovic, M., Karra, R. (2018) Endothelial Contributions to Zebrafish Heart Regeneration. Journal of cardiovascular development and disease. 5(4).
Abstract
Studies over the past two decades have shown heart regeneration in zebrafish to be a dynamic process, choreographed by multiple cell types. In particular, recent work has identified revascularization of the wound to be a sentinel event during heart regeneration. The cardiac endothelium has emerged as a key orchestrator of heart regeneration, influencing cardiomyocyte hyperplasia and tissue morphogenesis. Here, we review how the coronary vasculature regenerates after injury, how signaling pathways link the cardiac endothelium to heart regeneration, and how understanding these signaling dynamics can lead to targeted therapies for heart regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping