PUBLICATION
Understanding zebrafish aggressive behavior
- Authors
- Zabegalov, K.N., Kolesnikova, T.O., Khatsko, S.L., Volgin, A.D., Yakovlev, O.A., Amstislavskaya, T.G., Friend, A.J., Bao, W., Alekseeva, P.A., Lakstygal, A.M., Meshalkina, D.A., Demin, K.A., de Abreu, M.S., Rosemberg, D.B., Kalueff, A.V.
- ID
- ZDB-PUB-181127-62
- Date
- 2018
- Source
- Behavioural processes 158: 200-210 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Aggression, environmental, experimental models, modulation, pharmacology of aggression, zebrafish
- MeSH Terms
-
- Aggression/physiology*
- Animals
- Behavior, Animal/physiology*
- Brain/physiology*
- Zebrafish/physiology*
- PubMed
- 30468887 Full text @ Behav. Processes
Citation
Zabegalov, K.N., Kolesnikova, T.O., Khatsko, S.L., Volgin, A.D., Yakovlev, O.A., Amstislavskaya, T.G., Friend, A.J., Bao, W., Alekseeva, P.A., Lakstygal, A.M., Meshalkina, D.A., Demin, K.A., de Abreu, M.S., Rosemberg, D.B., Kalueff, A.V. (2018) Understanding zebrafish aggressive behavior. Behavioural processes. 158:200-210.
Abstract
Aggression is a common agonistic behavior affecting social life and wellbeing of humans and animals. However, the underlying mechanisms of aggression remain poorly understood. For decades, studies of aggression have mostly focused on laboratory rodents. The growing importance of evolutionarily relevant, cross-species disease modeling necessitates novel model organisms to study aggression and its pathobiology. The zebrafish (Danio rerio) is rapidly becoming a new experimental model organism in neurobehavioral research. Zebrafish demonstrate high genetic and physiological homology with mammals, fully sequenced genome, ease of husbandry and testing, and robust behavioral repertoire. As zebrafish present overt aggressive behaviors, here we focus on their behavioral models and discuss their utility in probing aggression neurobiology and its genetic, pharmacological and environmental modulation. We argue that zebrafish-based models represent an excellent translational tool to understand aggressive behaviors and related pathobiological brain mechanisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping