|ZFIN ID: ZDB-PUB-181127-10|
Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency
Zheng, Y., Liu, C., Li, Y., Jiang, H., Yang, P., Tang, J., Xu, Y., Wang, H., He, Y.
|Source:||Biology of reproduction 100(4): 1066-1072 (Journal)|
|Registered Authors:||Liu, Chao, Li, Yan, Wang, Han|
|PubMed:||30452546 Full text @ Biol. Reprod.|
Zheng, Y., Liu, C., Li, Y., Jiang, H., Yang, P., Tang, J., Xu, Y., Wang, H., He, Y. (2018) Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency. Biology of reproduction. 100(4):1066-1072.
ABSTRACTMechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1m/m; Per2m/m double mutations display a decrease in female fertility starting approximately at 20-week-old, with significantly less pups born from 32-week-old onwards. Histological analysis revealed that a significant reduction of ovarian follicles was observed in the Per1/Per2 mutants compared with the littermate controls examined at 26- and 52-week-old while the difference was not statistically significant between the two groups at 3- and 8-week-old. We further showed that vascular development including the ovarian follicle associated vascular growth appeared normal in the Per1/Per2 mutant mice, although clock genes were reported to regulate angiogenesis in zebrafish. The findings imply that loss-of-function mutations with Per1/Per2 result in a premature depletion of ovarian follicle reserve leading to the decline of reproductive capacity.
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